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However, it has been found that the pathological degradation of BBB hinders the proper delivery and action of therapeutic agents, due to a series of functional, structural, and biochemical changes at both the endothelial level and, consequently, in the perivascular and interstitial space [314]

Indeed, psychological (e.g., anxiety, depression, and stress [6]), hormonal (e.g., hypogonadism, hypothyroidism, hyperprolactinemia [7]), cardiovascular (e.g., hypertension, atherosclerosis, heart failure [8]), metabolic (e.g., obesity, metabolic syndrome, diabetes, dyslipidemia, gout [9,10]), neurologic (e.g., central and peripheral neuropathies [11,12,13]) risk factors can promote the development of ED [14], or its progression from subclinical to more severe forms [15]

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Safety and Side Effects BPC-157 is generally well tolerated when administered correctly